Breast cancer subtypes mortality

Metrics details. Limited evidence, mostly from studies in Western populations, suggests that the prognostic effects of lifestyle-related risk factors may be molecular subtype-dependent. Here, we examined whether pre-diagnostic lifestyle-related risk factors for breast cancer are associated with clinical outcomes by molecular subtype among patients from an understudied Asian population. In this population-based case series, we evaluated breast cancer risk factors in relation to year all-cause mortality ACM and 5-year recurrence by molecular subtype among women with invasive breast cancer in Sarawak, Malaysia. Subtypes luminal A-like, luminal B-like, HER2-enriched, triple-negative were defined using immunohistochemical markers for hormone receptors and human epidermal growth factor receptor 2 HER2 in conjunction with histologic grade.
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Recurrence Rate for Triple-Negative Breast Cancer

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Breast cancer survival by molecular subtype: a population-based analysis of cancer registry data

The relation between breast cancer molecular subtype and survival has been studied in several jurisdictions, but limited information is available for Ontario. The aim of this study was to determine breast cancer survival by molecular subtype and to assess the effect on survival of selected demographic and tumour-based characteristics. We estimated associations with predictor variables age, stage at diagnosis, histologic type, comorbidity and place of residence [urban or rural] using a multivariate Cox proportional hazards model. Likelihood ratio testing was used to evaluate differences in risk of death. Luminal A was the most commonly diagnosed subtype For all subtypes, a dose-response effect was observed between the hazard of death and age and stage at diagnosis, with the greatest effect found for the HER2-enriched subtype age: hazard ratio [HR] 7. Moderate comorbidity Charlson Comorbidity Index score 1 or 2 was associated with increased risk of death for triple-negative cancers HR 2.
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Breast cancer survival by molecular subtype: a population-based analysis of cancer registry data

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One of these subtypes is known as triple-negative breast cancer TNBC. TNBC grows rapidly. It also has a higher grade and tends to metastasize spread.
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